"Qualitative rapid test for antibodies to COVID-19-DIAQUICK COVID-19 IgG/IgM"
Testing for SARS-CoV-2 coronavirus is one of the most important elements of the fight against COVID-19
Conducting mass tests for the SARS-CoV-2 coronavirus with subsequent isolation for those infected with the coronavirus and adequate treatment for patients with already existing initial symptoms of COVID-19 is one of the most important measures to combat the pandemic.
As is already known, almost half of those infected with the new coronavirus do not have any symptoms, but, nevertheless, they are contagious and can pose a danger to others. Therefore, testing as many people as possible of all categories of risk groups can prevent the increasing spread of COVID-19.
Currently, there are several types of tests used (including express tests) for SARS-CoV-2.
It is believed that the most sensitive test is the PCR test (up to 100%), but it can hardly be attributed to express tests. Ideally, it can be carried out in a few hours, but in practice, even in Moscow, the result can be obtained only 2-3 days after taking the analysis (and it is quite possible that the person at the time of taking the analysis was not infected yet, but when receiving the result already became so).
Moreover, the PCR test is resource-intensive and its implementation requires a special high-tech laboratory and trained specialists, which is not always observed in reality. As a result, this theoretically the most sensitive test in practice is reliable only in 60% of cases. Mass testing is hindered not only by the time until the results are received, but also by the high price for conducting it (3-5 thousand rubles for taking a sample at home).
Another test is the coronavirus antigen test. To carry it out, a smear is taken from the nose or the back wall of the pharynx (as for a PCR test), the result can be obtained after 10-15 minutes. Antigen tests have a very high specificity (up to 100%), so false positive results are rare. But the sensitivity of these tests is insufficient - from 84% to 97%, which is manifested by a large number of false negative results.
The next, largest group in terms of the number of tests registered in Russia for the determination of coronavirus is tests for the determination of antibodies.
For reference: antibodies are protein molecules (immunoglobulins) produced by blood B-lymphocytes in response to foreign agents entering the body, in our case, the SARS-CoV-2 coronavirus. Antibodies to various pathogens of infectious diseases are specific and their presence in the blood gives information about the presence of infection and even about the course of the disease (acute or advanced phase).
The test determines two types of antibodies - IgM and IgG immunoglobulins.
IgM immunoglobulins begin to be produced in response to infection, appear in the acute phase of the disease (5-7 days after the onset of the disease); IgG immunoglobulins appear in the blood 10-14 days after the onset of the disease. They provide the immune response (humoral) of the body to fight infection.
Thus, if IgM(+) is determined as a result of the test – the patient is in the acute phase of the disease, IgG(+) is the subject or has had a coronavirus infection and has developed an immune response or, in the presence of clinical manifestations of COVID-19, he has an advanced stage of COVID-19.
The subspecies of antibody tests are enzyme immunoassay (ELISA) and immunochromatographic analysis (IHA). For enzyme immunoassay (ELISA), as well as for PCR, a laboratory is required, the time to obtain the result is 1-2 days. In addition, venous blood sampling is required for ELISA. The above, despite the very good specificity and sensitivity of ELISA, makes it impossible to use this type of tests for rapid testing for coronavirus.
Immunochromatographic analysis (ICA) for IgM and IgG antibodies is the most suitable for conducting rapid tests for COVID-19. Basically, it has excellent specificity and sensitivity (from 85% to 95%), the time to get the result is 10-15 minutes, the material for the study can be not only serum, plasma and venous blood (necessary for ELISA), but also capillary blood, which makes it possible to conduct an express test at the patient's bedside and in any other necessary places.
Among the group of leaders of IHA tests stands out"High-quality rapid test for antibodies to COVID-19 - DIAQUICK COVID-19 IgG/IgM". The test manufacturer is a leading Austrian company for the production of chemical and technical products and laboratory devices - DIALAB Produktion und Vertrieb von chemisch-technischen Produkten und Laborinstrumenten Gesellschaft m.b.H.
The main advantage "DIAQUICK COVID-19 IgG/IgM"& nbsp;are 100% sensitivity and 100% specificity, confirmed by Russian clinical and laboratory studies conducted at the Central Clinical Hospital of the Russian Academy of Sciences. Outstanding diagnostic functional characteristics (100% specificity, sensitivity, depending on the number of days since the appearance of the first symptoms - up to 100%) are also confirmed by studies conducted by the Pasteur Institute in Paris (Centre National de Reference). They also noted the ease of use and good clarity of the test. The time to receive the test results is 7-15 minutes.
Of course, as prescribed by Roszdravnadzor, this test provides only preliminary results, the diagnosis must be confirmed by an alternative testing method and clinical manifestations, but given the unique characteristics of the test, it can be successfully used for mass rapid testing to combat the coronavirus pandemic.
Buy DIALAB test - https://dialab.x-tech.su/
Conducting mass tests for the SARS-CoV-2 coronavirus with subsequent isolation for those infected with the coronavirus and adequate treatment for patients with already existing initial symptoms of COVID-19 is one of the most important measures to combat the pandemic.
As is already known, almost half of those infected with the new coronavirus do not have any symptoms, but, nevertheless, they are contagious and can pose a danger to others. Therefore, testing as many people as possible of all categories of risk groups can prevent the increasing spread of COVID-19.
Currently, there are several types of tests used (including express tests) for SARS-CoV-2.
It is believed that the most sensitive test is the PCR test (up to 100%), but it can hardly be attributed to express tests. Ideally, it can be carried out in a few hours, but in practice, even in Moscow, the result can be obtained only 2-3 days after taking the analysis (and it is quite possible that the person at the time of taking the analysis was not infected yet, but when receiving the result already became so).
Moreover, the PCR test is resource-intensive and its implementation requires a special high-tech laboratory and trained specialists, which is not always observed in reality. As a result, this theoretically the most sensitive test in practice is reliable only in 60% of cases. Mass testing is hindered not only by the time until the results are received, but also by the high price for conducting it (3-5 thousand rubles for taking a sample at home).
Another test is the coronavirus antigen test. To carry it out, a smear is taken from the nose or the back wall of the pharynx (as for a PCR test), the result can be obtained after 10-15 minutes. Antigen tests have a very high specificity (up to 100%), so false positive results are rare. But the sensitivity of these tests is insufficient - from 84% to 97%, which is manifested by a large number of false negative results.
The next, largest group in terms of the number of tests registered in Russia for the determination of coronavirus is tests for the determination of antibodies.
For reference: antibodies are protein molecules (immunoglobulins) produced by blood B-lymphocytes in response to foreign agents entering the body, in our case, the SARS-CoV-2 coronavirus. Antibodies to various pathogens of infectious diseases are specific and their presence in the blood gives information about the presence of infection and even about the course of the disease (acute or advanced phase).
The test determines two types of antibodies - IgM and IgG immunoglobulins.
IgM immunoglobulins begin to be produced in response to infection, appear in the acute phase of the disease (5-7 days after the onset of the disease); IgG immunoglobulins appear in the blood 10-14 days after the onset of the disease. They provide the immune response (humoral) of the body to fight infection.
Thus, if IgM(+) is determined as a result of the test – the patient is in the acute phase of the disease, IgG(+) is the subject or has had a coronavirus infection and has developed an immune response or, in the presence of clinical manifestations of COVID-19, he has an advanced stage of COVID-19.
The subspecies of antibody tests are enzyme immunoassay (ELISA) and immunochromatographic analysis (IHA). For enzyme immunoassay (ELISA), as well as for PCR, a laboratory is required, the time to obtain the result is 1-2 days. In addition, venous blood sampling is required for ELISA. The above, despite the very good specificity and sensitivity of ELISA, makes it impossible to use this type of tests for rapid testing for coronavirus.
Immunochromatographic analysis (ICA) for IgM and IgG antibodies is the most suitable for conducting rapid tests for COVID-19. Basically, it has excellent specificity and sensitivity (from 85% to 95%), the time to get the result is 10-15 minutes, the material for the study can be not only serum, plasma and venous blood (necessary for ELISA), but also capillary blood, which makes it possible to conduct an express test at the patient's bedside and in any other necessary places.
Among the group of leaders of IHA tests stands out"High-quality rapid test for antibodies to COVID-19 - DIAQUICK COVID-19 IgG/IgM". The test manufacturer is a leading Austrian company for the production of chemical and technical products and laboratory devices - DIALAB Produktion und Vertrieb von chemisch-technischen Produkten und Laborinstrumenten Gesellschaft m.b.H.
The main advantage "DIAQUICK COVID-19 IgG/IgM"& nbsp;are 100% sensitivity and 100% specificity, confirmed by Russian clinical and laboratory studies conducted at the Central Clinical Hospital of the Russian Academy of Sciences. Outstanding diagnostic functional characteristics (100% specificity, sensitivity, depending on the number of days since the appearance of the first symptoms - up to 100%) are also confirmed by studies conducted by the Pasteur Institute in Paris (Centre National de Reference). They also noted the ease of use and good clarity of the test. The time to receive the test results is 7-15 minutes.
Of course, as prescribed by Roszdravnadzor, this test provides only preliminary results, the diagnosis must be confirmed by an alternative testing method and clinical manifestations, but given the unique characteristics of the test, it can be successfully used for mass rapid testing to combat the coronavirus pandemic.
Buy DIALAB test - https://dialab.x-tech.su/
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